Active substances: Isotretinoin
Patients reporting any suicidal behaviour including attempts, interrupted attempts, aborted attempts, or other preparatory behaviours, within the past year, or serious suicidal ideation in the past year, will be excluded from study participation.
A lifetime history of wishing to be dead, non-specific active suicidal thoughts or active suicidal ideation without intent to act will not result in exclusion. Known history or suspected carcinoma.
Known history of liver or kidney disorders hepatic and renal insufficiency. Known history or current pseudotumor cerebri benign intracranial hypertension.In no patient was the treatment discontinued due to the abnormality in was 10 months.
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