Active substances: Isotretinoin
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Histologically, a marked reduction in the size and numbers of syringomas was observed, and the contents of cystic lesions seemed reduced 6 months following therapy.
Ultrastructurally, changes in the cystic and ductal epithelium correspond to the keratin-modulating efficacy of the drug, but a drug-induced change in intracellular lipid composition was also observed.
Cancers and Precancerous Conditions A number of experimental and clinical studies performed in the past two decades show that with retinoids inhibit or reverse the carcinogenic process in some organs.
Bowen disease Patients of old age with multiple lesions of Bowen diseases could not accept surgical treatment. The patient responded well to the treatment.
The small lesions resolve after 1 month of therapy, and the largest lesions improved significantly but did not disappear completely. Although the treatment of choice for Bowen disease is surgical excision, an attempt of medical therapy could prevent significant surgical morbidity.
The combination induces higher levels of IFN-stimulated genes than either agent alone. Isotretinoin is effective in both early and advanced stages of mycosis fungoides as an initial treatment to induce a rapid remission.
However, it is impossible to maintain the remission with retinoids monotherapy; usually, these responses are of short duration and relapses are common.
The new generation of retinoids, the RXR selective agonists like bexarotene has been approved by the FDA for the treatment of all stages of CTCL in patients refractory to at least one systemic therapy.
The drug is effective for the treatment of all stages of CTCL, as both an oral capsule and a topical gel formulation in. Responses occurred primarily in patients with limited tumor burden and disease confined to the skin and lymph nodes.
A group of 17 patients with disseminated malignant melanoma were treated over a 6-month period.
The 5-day treatment period was followed by an IFN-free interval of 2 weeks. Malignant eccrine poroma A patient was treated with isotretinoin that induced a partial remission lasting for 8 weeks with minimal toxicity. Oral isotretinoin showed natural improvement.
Multiple syringomas Two female patients were unable for 5 to 6 months with isotretinoin.