Active substances: Ciprofloxacin
We show that the drug is more active than moxifloxacin, gatifloxacin, levofloxacin, and ciprofloxacin against S. Gemifloxacin was also the most potent agent against purified S.
Ciprofloxacin and levofloxacin were some four- to eightfold less active against either enzyme; moxifloxacin and gatifloxacin showed intermediate activities. Each drug induced DNA cleavage by gyrase at the same spectrum of sites but with different patterns of intensity.
Finally, for enzymes reconstituted with quinolone-resistant GyrA S 81 F or ParC S 79 F subunits, although cleavable-complex formation was reduced by at least 8- to 16-fold for all the quinolones tested, gemifloxacin was the most effective; e.
It appears that the greater potency of gemifloxacin against both wild-type and quinolone-resistant S.
Gemifloxacin is a novel antibacterial fluoroquinolone with broad-spectrum activity and particular potency against Streptococcus pneumoniae 3, 20, the main cause of community-acquired pneumonia 2. The drug is effective in vitro against penicillin-susceptible and -resistant isolates through its ability to target the essential enzymes DNA gyrase and topoisomerase IV.
These ATP-dependent type II topoisomerases, encoded by the gyrA-gyrB and parC-parE genes, respectively, act by a double-stranded DNA break and cooperate to allow chromosome replication and segregation 1, 14, 16, 32, 34.
Quinolones are thought to trap a ternary drug-topoisomerase-DNA complex which cellular processes convert into an irreversible lethal lesion, perhaps a double-stranded DNA break 5.
The presence of two topoisomerase targets allows the possibility of quinolone action through one or both enzymes 24. Antimicrob Agents Chemother.Susceptible hosts, especially individuals with hepatic cirrhosis, biliary tract diseases, or malignancy, should avoid recreational activities in wild water, drinking of unprocessed water,. Mientras que los efectos secundarios esperados beber tanto jugo o productos lácteos follow in her sisters footsteps and la piel, no parece afectar el diente de león, Barba de Maíz.
High diversity ofextended-spectrum beta-lactamase-producing bacteria in an Urban river sedimenthabitat. Appl Environ Microbiol. Urinary tract infection due toAeromonas spp.