Active substances: Ciprofloxacin
Body weight was derived from a large PIRRT study and pharmacokinetic data from published ciprofloxacin and levofloxacin pharmacokinetic studies in critically ill patients receiving RRT. In order to avoid spurious simulations, limits were obtained from those previous studies and were set for all input parameters.
The ranges of volume of distribution V d and non-renal clearance values CLNR were extracted from the relevant ciprofloxacin and levofloxacin pharmacokinetic studies. The correlation i. Clusters of cases of IE occur particularly in abusers of pentazocine and tripelennamine, likely due to mixing of drugs with contaminated water.
IE in patients with IDU frequently have no preceeding valvular or heart disease. The specific heart valve involved is important with respect to clinical manifestations, therapy, and prognoses 88.
Gram-negative bacterial infection must be considered, especially when erosion or perforation of the bowel has occurred from a VP shunt catheter, leading to an ascending CNS infection.
Mortality is highest if infection results from bacteremia in an immunosuppressed host, underlying infective endocarditis, or malignant otitis externa.
Cure is more likely if the meningitis results from neurosurgical procedures involving hardware, such as VP shunts, drains, or reservoirs.
Ocu lar Infections P. Pain is found in 97. Inflammation can be secondary to dermatitis only or it can be caused by active bacteria.
Acute otitis externa can occur acutely and become painful. Wax in the ear can swell and block the canal and dampen hearing to varying degrees, creating a temporary conductive hearing loss. The cohort database was continually updated until the inclusion of five patients who were subjected to an overdose and who were initially admitted to the medical intensive care unit and then transferred to our department for acute renal failure ARF due to ciprofloxacin ingestion requiring urgent hemodialysis.
Renal ultrasound was normal in all cases. Twenty-four-hour proteinuria was present but not significant in one case, while microscopic hematuria was present in one case.
Treatment consisted of supportive therapy and extrarenal purification by conventional intermittent hemodialysis. FormalPara Key Points Drug-induced nephrotoxicity is one of the leading causes of acute kidney injury worldwide.
Nephrotoxicity of ciprofloxacin is often underestimated. In addition to causing acute kidney injury, chronic drug toxicity can in some cases lead to chronic kidney disease and eventually end-stage renal disease.