Active substances: Doxycycline
This article has been cited by other articles in PMC. Abstract Omadacycline is a first-in-class aminomethylcycline antibiotic with microbiological activity against Gram-positive and Gram-negative aerobes and anaerobes and atypical bacteria that is being developed for the treatment of acute bacterial skin and skin structure infections ABSSSI and community-acquired bacterial pneumonia CABP.
The bioavailability of a phase 3 tablet formulation relative to that obtained via intravenous i. Subjects received omadacycline at 100 mg i.
Twenty of 24 subjects completed all treatment periods. The two tablet formulations produced equivalent total exposures. The phase 3 tablet produced an exposure equivalent to that of the 100-mg i.
The absolute bioavailability of the tablets was approximately 34. Single oral and i.
A 300-mg dose of the tablet formulation of omadacycline intended for use in phase 3 studies produced a total exposure equivalent to that of a 100-mg i. In addition, omadacycline is active against bacterial pathogens that express the two forms of tetracycline resistance.
In a phase 2 study with patients with complicated skin and skin structure infections, omadacycline demonstrated efficacy and tolerability that were comparable to those of linezolid 7.
Clinical development is proceeding to evaluate omadacycline as a treatment for acute bacterial skin and skin structure infections ABSSSI and community-acquired bacterial pneumonia CABP. Both intravenous i.
Therefore, a 300-mg oral dose was expected to provide consistent total omadacycline exposure as measured by AUC relative to a 100-mg i. Earlier oral capsule and table formulations of omadacycline were used in clinical studies, but a new oral tablet formulation containing a more stable tosylate polymorph was developed in an attempt to improve oral absorption.
However you're less likely to feel sick if you have it with food. It's important to take doxycycline while you're in an upright position.
You can be sitting, standing or walking. This will stop the medicine irritating your food pipe or stomach. What if I forget to take it?
If you forget to take a dose, take it as soon as you remember, unless it's nearly time for your next dose.
In this case, just leave out the missed dose and take your next dose as normal. Never take 2 doses at the same time. Never take an extra dose to make up for a forgotten one.
You could also ask your pharmacist for advice on other ways to remember your medicines.
What if I take too much? Accidentally taking an extra dose of doxycycline is unlikely to harm you. Speak to your pharmacist or doctor if you're worried or you take more than 1 extra dose.
Side effects Like all medicines, doxycycline can cause side effects, although not everyone gets them.