Active substances: Doxycycline
Speak to your pharmacist or doctor if you're worried or you take more than 1 extra dose. Side effects Like all medicines, doxycycline can cause side effects, although not everyone gets them.
Common side effects These common side effects happen in around 1 in 10 people. Keep taking the medicine, but talk to your doctor or pharmacist if these side effects bother you or don't go away: headaches feeling or being sick nausea or vomiting being sensitive to sunlight Serious side effects are rare and happen in less than 1 in 1,000 people.
In rare cases, doxycycline can cause a serious allergic reaction anaphylaxis. These are not all the side effects of doxycycline.
For a full list see the leaflet inside your medicines packet.
Information: You can report any suspected side effect to the UK safety scheme. How to cope with side effects What to do about: headaches - make sure you rest and drink plenty of fluids.
Everyday painkillers, such as paracetamol and ibuprofen, are safe to take with doxycycline. It might help to take your doxycycline after a meal or snack but avoid dairy products like milk, cheese and yoghurt. Dairy products can stop your body absorbing your medicine properly.
If you are being sick, drink plenty of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee.
American Cyanamid was one of these, and in the late 1940 s chemists there discovered chlortetracycline, the first member of the tetracycline class of antibiotics.
Both compounds, like penicillin, were natural products and it was commonly believed that nature had perfected them, and further chemical changes could only degrade their effectiveness. Scientists at Pfizer led by Lloyd Conover modified these compounds, which led to the invention of tetracycline itself, the first semi-synthetic antibiotic.
Charlie Stephens' group at Pfizer worked on further analogs and created one with greatly improved stability and pharmacological efficacy: doxycycline. It was clinically developed in the early 1960 s and approved by the FDA in 1967.
At 1-month follow-up, persistent dysarthria remained, but other symptoms had resolved completely. Despite treatment with oral doxycycline for presumptive LD, symptoms persisted; development of bilateral leg weakness, confusion, and diplopia prompted evaluation at the local hospital 1 week after symptom onset.
He was afebrile and hemodynamically stable; physical examination revealed decreased alertness, bilateral proximal leg weakness, and absence of neck rigidity. Further questioning revealed a history of 2 transient rashes 1 each on trunk and arm 1 week before symptom onset, but they were not visible on physical examination.
He received intravenous vancomycin, ceftriaxone, and acyclovir. Ceftriaxone was discontinued after the LD test result was negative. Results of all other infectious disease tests were negative Technical Appendix, Table.