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    The publisher's final edited version of this article is available at Lancet flashes cite the published article.

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    Max dose 1200 mg every 8 hours. Differences and percentage changes from baseline to week 4 or week 8 were calculated for each of the three measures.

    A mixed-effect model was used for comparison of the treatment effect on these measures.

    The fixed effects in the model included treatment group three strata, time two strata, 4 weeks and 8 weeks and baseline measures.

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    A random effect for participants was also included in the model. The assumptions made for mixed-effect models normality of error terms, mean, and covariance structure were checked thoroughly by use of residual plots.

    Outliers were identified and their influence on model estimation was examined.

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  • For purposes of comparison, simpler analyses were also done on change scores and percentage change scores at week 4 and week 8 separately, by ANCOVA. The drug and placebo were provided by Pfizer, Inc.


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    The study was reviewed and approved by the National Cancer Institute, but not by Pfizer, and neither funding source had any role in study design; collection, analysis, or interpretation of data; or the writing of the report.

    During the 4-week titration phase, patients were started on one 300-mg capsule of gabapentin or matching placebo.


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    METHODS: The study hypothesis was defined a priori as a lower 4-week migraine rate during the second stabilization period for the gabapentin-treated patients as compared with the placebo-treated patients.

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