Active substances: Gabapentin
In addition, gabapentin is associated with a high incidence of dizziness and somnolence [ Rowbotham et al.
A once-daily gastroretentive formulation of gabapentin Gralise, Depomed Inc. This article reviews the properties of once-daily gastroretentive gabapentin and its demonstrated efficacy and tolerability in the treatment of PHN.
Pharmacokinetics The pharmacokinetics of gabapentin TID have been described in detail elsewhere [ Vollmer et al.
Gabapentin is not appreciably bound to plasma proteins or metabolized and is almost completely eliminated unchanged by renal excretion.
The incidence of PHN increases in elderly patients, with 75 percent of those over 70 years old who have shingles, developing PHN.Abstract Background and Objectives There are limited data examining the real-world use of gabapentin and pregabalin for the treatment of post-herpetic neuralgia PHN.
The pain associated with PHN reportedly can be so severe that patients are unable to resume normal activities for months. Approximately 70,000 to 100,000 Americans are affected by PHN each year.
The pain associated with PHN can interfere with daily activities such as sleep and recreational activities and can be associated with clinical depression.
Conclusion It appears that gabapentin and pregabalin are not used effectively to treat PHN. A common cause of neuropathic pain is post-herpetic neuralgia PHN, a complication of herpes zoster.
Because of the acute pain associated with PHN, quality of life is often negatively affected.
Antiepileptic medications and tricyclic antidepressants have been the mainstay of pharmacological treatment of neuropathic pain.
In two large multicentre studies, patients with PHN treated with gabapentin experienced significant reductions in pain compared with patients receiving placebo. Patients on gabapentin also showed significantly less sleep interference and improvements in mood.
Pregabalin has been shown to be effective and tolerable in patients treated for neuropathic pain associated with PHN.
The beneficial effect of tricyclic antidepressants e.
Because both gabapentin and pregabalin must be titrated to an effective dosage and continued for an adequate duration to alleviate the pain associated with PHN, we were interested to determine how many patients with PHN receive effective dosages of these therapies and how long they continue them in real-world practice.
The types and incidence of adverse events were similar across age groups except for peripheral edema, which tended to increase in incidence with age.
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