Active substances: Gabapentin
How Dangerous is Gabapentinoid Abuse?
Gabapentinoid overdoses can range from exhibiting benign symptoms to resulting in death. A review by Evoy, et al, observed six cases of pregabalin overdose and 31 cases of gabapentin overdose.
Another patient who overdosed on gabapentin a 91,000-mg dose with co-ingestion of valproic acid and alcohol experienced symptoms of drowsiness, dizziness, and slurred speech.
Two cases of pregabalin overdose resulted in death due to pregabalin poisoning involving co-ingestants.
The main cause of death for both patients was listed as pregabalin toxicity but the dose taken and determined cause of death was not reported.
In the case of gabapentin, two of the three recorded fatal overdoses were due to gabapentin alone. One of these patients was found to have consumed up to 15. Both were found unresponsive due to cardiorespiratory compromise as a result of gabapentin toxicity.
Recent Regulations on Gabapentin As noted, gabapentin, unliked pregabalin, is not currently considered a federally controlled substance in the United States. But if you're dizzy, unsteady or drowsy, avoid any activities — such as driving or operating machinery — that could be dangerous.
Side effects sometimes occur because of a combination of drugs you're taking. Gabapentin doesn't generally interact with other medications, but antacid medications, such as Maalox, can affect the way your body absorbs gabapentin.
It made me very depressed and I stopped it. Lyrica had just come out so my surgeon then put me on that.
I guess not much thought went into my side effect of Neirontin since they are basically the same!
I then became full of despair from Lyrica, with personality changes such as screaming at others with anger because I was in so much pain…something I would never ever have normally done.
The office manager told me to go see a psychiatrist! Hence, I stopped that med immediately and the poor effects vanished.
In I was now seeing a Pain Management doc for chronic pain meds my 4 spine surgeries disabled me and I live with severe chronic pain.
I was still suffering with awful sciatic and other nerve pain. He put me on Gabapentin. I could only tolerate the 300 mg long acting dose called Gralise though.
Anything stronger and I was a mess! But, it helped the nerve pain so I stuck with it and eventually just got somewhat used to the poor side effects. I went on to take it for 12 years. Last year I was also diagnosed Systemic Lupus.
It was amazing! Plus, I have no nerve pain but on rare occasion if I overdo activity. Incorporate the Ora-Plus into the gabapentin and mix into a smooth paste.