Active substances: Norfloxacin
This might increase the risk of methotrexate toxic reactions. Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer. At the respective doses, mean peak serum and plasma concentrations of 0.
The effective half-life of norfloxacin in serum and plasma is 3—4 hours. Steady-state concentrations of norfloxacin will be attained within two days of dosing. Norfloxacin is least soluble at urinary pH of 7.
Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent. What you need to know before you take Norfloxacin 400 mg 3.
How to take Norfloxacin 400 mg 4. Possible side effects 5.
How to store Norfloxacin 400 mg 6. Contents of the pack and other information 1.
What Norfloxacin 400 mg is and what it is used for Norfloxacin the active ingredient contained in Norfloxacin 400 mg belongs to a group of antibiotics called quinolones which work by killing bacteria that cause infections.
This medicine is indicated for the treatment of bacterial infections of the urinary tract e. If you experience tendon pain or signs of inflammation of the Achilles tendon stop taking your medicine and contact your doctor and rest the affected limb.
Providing you do not have a problem with your heart or kidneys, you should drink plenty of liquid whilst taking this medicine.CHMP stated that doctors should not prescribe oral norfloxacin for complicated pyelonephritis withdrawn as a result of infection to an alternative antibiotic. It licensed use in acute and chronic complicated kidney infections has been and should consider switching patients already taking oral norfloxacin for this type.
These crystals cannot be seen by the naked eye. Drinking plenty of liquid can help prevent this occurring.
If you develop severe and persistent diarrhoea whilst you are taking your tablets or after stopping your tablets you should consult your doctor.
Other medicines and Norfloxacin 400 mg Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. You must tell your doctor if you are taking other medicines that can alter your heart rhythm: medicines that belong to the group of anti-arrhythmics e.