Active substances: Norfloxacin
Anquandah, Virender K. Sharma.
Efficient tetracycline adsorptive removal using tricaprylmethylammonium chloride conjugated chitosan hydrogel beads: Mechanism, kinetic, isotherms and thermodynamic study. International Journal of Biological Macromolecules, 155, 421-429.
Sean T. McBeath, David P. Wilkinson, Nigel J. Analytical quantification of aqueous permanganate: Direct and indirect spectrophotometric determination for water treatment processes.
Chemosphere, 251, Oxidation of iodide and hypoiodous acid by non-chlorinated water treatment oxidants and formation of iodinated organic compounds: A review. As such, these drug interactions involving the fluoroquinolones appear to be drug specific rather than a class effect.
The fluoroquinolones have also been shown to interfere with the metabolism of caffeine and the absorption of levothyroxine. This might increase the risk of methotrexate toxic reactions.
Current or past treatment with oral corticosteroids is associated with an increased risk of Achilles tendon rupture, especially in elderly patients who are also taking the fluoroquinolones.
Careful monitoring and supportive treatment, monitoring of renal and liver function, and maintaining adequate hydration is recommended by the manufacturer.
At the respective doses, mean peak serum and plasma concentrations of 0. The effective half-life of norfloxacin in serum and plasma is 3—4 hours. Steady-state concentrations of norfloxacin will be attained within two days of dosing.
Norfloxacin is least soluble at urinary pH of 7. Other companies initiated fluoroquinolone discovery programs in the aftermath of the publication of the norfloxacin patent.
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