Active substances: Ivermectin
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ART induces autophagy, based on the observations that ART increased autophagosomes formation and enhanced autophagic flux.
It is possible that enhanced lysosomal degradation of ferritin induced by ART leads to the transient increase of cytosolic ferrous iron, which then affects the mitochondria, leading to enhanced mitochondrial ROS production.
Therefore, lysosomal inhibitors significantly protect the cells from ART-induced cell death via blockage of ferritin degradation.
DFO is iron chelator which inhibits cell death. Images courtesy of Yang, Nai-Di, et al.
Therefore it has been speculated that the effect of Artemisinin in the lysosome is to impair the microtube motor proteins. This perinuclear clustering of organelles is a prelude to programmed cell death.
Left image: Top Row are Untreated Breast Cancer Cells showing lysosomes dark stained particles dispersed throughout cells. Ovide malathion product information.
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His past medical and surgical history is unremarkable. This product contains benzyl alcohol and is determined as Pregnancy Category B.