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Genetic, environmental, and behavioral factors influence the development of obesity, and both the general public and health professionals stigmatize those who suffer from the disease. Obesity is associated with and contributes to a shortened life span, type 2 diabetes mellitus, cardiovascular disease, some cancers, kidney disease, obstructive sleep apnea, gout, osteoarthritis, and hepatobiliary disease, among others.
Weight loss reduces all of these diseases in a dose-related manner—the more weight lost, the better the outcome. Weight loss is best achieved by reducing energy intake and increasing energy expenditure.
Programs that are effective for weight loss include peer-reviewed and approved lifestyle modification programs, diets, commercial weight-loss programs, exercise programs, medications, and surgery.
Over-the-counter herbal preparations that some patients use to treat obesity have limited, if any, data documenting their efficacy or safety, and there are few regulatory requirements.
Weight regain is expected in all patients, especially when treatment is discontinued. When making treatment decisions, clinicians should consider body fat distribution and individual health risks in addition to body mass index.
Evidence of obesity in humans can be found in primitive art that dates back to the Paleolithic age 4. Two thousand five hundred years ago, Hippocrates cautioned that sudden death is more common in those who are naturally fat than lean 5.
In 1760, the English physician Malcolm Flemyng wrote that obesity can be called a disease, because it obstructs the free exercise of the animal functions and can shorten life 6.
Modern concepts of the pathophysiology of obesity date back to the end of the 18 th century when Antoine Lavoisier established that life was synonymous with oxidation 8. More than 100 years later, Atwater and Rosa 9 applied the laws of thermodynamics to human beings, and during the 20 th century, researchers discovered that hypothalamic tumors and tumors of the pituitary gland could cause obesity 10—12.Leaving that place takes a lot of yellow.