Active substances: Azithromycin
Stephen E. Malaria can be treated or prevented with the broad-spectrum antimicrobial drugs tetracycline or azithromycin AZT 1.
In vitro, AZT interferes with malarial parasite replication by targeting the unique apicoplast organelle of the parasite 1. AZT might interfere with transmission by exoerythrocytic inhibition of parasite liver stages in humans and mice 3 and by interference with ookinete and sporozoite production in mosquitoes 4.
Monotherapy with AZT is not typically used to treat malaria. However AZT is highly effective against Chlamydia trachomatis, the causative agent of trachoma, which causes blindness 5. Porco et al.Abstract Objectives Antibacterial efficacy of azithromycin could be improved by achieving higher requiring open-chest surgery for lung resection.
Plasmodium spp. However, in vitro selection for AZT resistance identified a G 76 V mutation among conserved active site amino acids at position 71—79 in P.
In the current study, we evaluated malaria prevalence in a cohort of 2,053 children and adults in central Tanzania to examine the effect of single dose AZ MDA on prevalent malaria infections. We also searched for PfRpL 4 mutations that might confer P.
Methods Study Site and Sampling Study participants were from 8 rural agricultural villages in Dodoma Province, central Tanzania 18 — 20. AZT was offered to all the residents of the treatment villages, including residents not part of the follow-up investigation.
Follow-up fingerprick blood sampling was performed at baseline and at 1, 4, and 6 months later.
Children were divided into 3 subgroups that were sampled once at weeks 2 group 1, 6 group 2, and 8 group 3. Contemporaneous to the monthly blood sampling, staff members from villages conducted an active surveillance program in which children were visited weekly and screened for axillary temperature and questionnaires were answered regarding fever, diarrhea, and respiratory disease 18, 19.
RDTs were performed by trained study staff and interpreted in the field at the time of sampling.